Key SYBARIS Objectives

• To identify biomarkers of drug sensitivity and resistance in fungal microorganisms, producing a comprehensive knowledgebase of drug resistance genes for multiple safe and pathogenic species;
• To advance understanding of fundamental mechanisms of immunomodulation by antifungal drugs in the clinical context of host-pathogen interactions, developing high confidence models of drug action, resistance and toxicity;
• To identify high-precision genetic signatures of susceptibility and sensitivity to fungal infection in immunocompromised and normal patients;
• To identify potential novel candidate molecules for future antifungal drugs and develop them for clinical trials;
• To set the groundwork for, and to serve as an example of a multidisciplinary systems biology approach to the study and treatment of infectious disease, bridging clinical immunology, human and fungi genetics and pharmacology with bioinformatics to answer fundamental questions of antimicrobial resistance.